Zfass A M, McHenry L, Sanyal A J
Division of Gastroenterology, Medical College of Virginia, Richmond.
Gastroenterologist. 1993 Mar;1(1):83-7.
Gastric acid produced by the parietal cells has a significant role in a variety of gastrointestinal diseases, such as duodenal ulcer, gastric ulcer, and gastroesophageal reflux disease. We address acid production by the parietal cell and the pharmacological means to control gastric acid secretion. The physiology of parietal cell acid secretion is reviewed. The role of acid-suppressive therapy with histamine H2 antagonists and omeprazole in duodenal ulcer, gastric ulcer, and gastroesophageal reflux disease is discussed. Pharmacology, side-effect profile, and dosage requirements of the histamine H2 antagonists and omeprazole are outlined.
壁细胞产生的胃酸在多种胃肠道疾病中起重要作用，如十二指肠溃疡、胃溃疡和胃食管反流病。我们探讨壁细胞的酸分泌以及控制胃酸分泌的药理学方法。回顾了壁细胞酸分泌的生理学。讨论了组胺H2拮抗剂和奥美拉唑在十二指肠溃疡、胃溃疡和胃食管反流病中的抑酸治疗作用。概述了组胺H2拮抗剂和奥美拉唑的药理学、副作用及剂量要求。
