Sardelic F, Fletcher J P, Ao P Y, Bilous M
Department of Surgery, University of Sydney and Westmead Hospital, NSW, Australia.
Cardiovasc Surg. 1994 Apr;2(2):237-41.
The search for an optimal prosthetic vascular graft suitable for small vessels continues. The aim of this study was to compare a fluoropolymer passivated Dacron graft with a standard polytetrafluoroethylene graft. A sheep animal model was used. Under general anaesthesia a 5-cm length of 5-mm diameter graft was interposed into the left carotid artery. After an interval of 1, 2 or 3 months the sheep were reanaesthetized and a carotid angiogram performed before harvesting the graft. Graft patency was assessed by macroscopic inspection, angiography and histological examination. Overall, four of eight polytetrafluoroethylene grafts and three of ten fluoropolymer passivated Dacron grafts remained patent with similar patency rates at 1, 2 and 3 months. Histological examination of all available grafts showed evidence of fibrointimal hyperplasia. All but one of the occluded grafts had fibrointimal hyperplasia.
寻找适合小血管的最佳人工血管移植物的工作仍在继续。本研究的目的是比较氟聚合物钝化涤纶移植物与标准聚四氟乙烯移植物。采用绵羊动物模型。在全身麻醉下，将一段5厘米长、直径5毫米的移植物植入左颈动脉。间隔1、2或3个月后，对绵羊再次进行麻醉，并在摘取移植物前进行颈动脉血管造影。通过宏观检查、血管造影和组织学检查评估移植物通畅情况。总体而言，八个聚四氟乙烯移植物中有四个、十个氟聚合物钝化涤纶移植物中有三个在1、2和3个月时保持通畅，通畅率相似。对所有可用移植物的组织学检查显示有纤维内膜增生的迹象。除一个闭塞移植物外，所有闭塞移植物均有纤维内膜增生。
