Kirby T J, Rice T W
Department of Thoracic and Cardiovascular Surgery, Cleveland Clinic Foundation, Ohio.
Chest Surg Clin N Am. 1994 May;4(2):217-25.
In North America, the character of esophageal carcinoma is changing. In most centers, adenocarcinoma of the esophagus is the predominant cell type and Barrett's esophagus is seen in many of these patients. Although this metaplastic transformation appears to be a major factor in the changing epidemiology of esophageal carcinoma, it is not the sole explanation for this shift from squamous cell carcinoma to adenocarcinoma.
在北美，食管癌的特征正在发生变化。在大多数医疗中心，食管腺癌是主要的细胞类型，许多此类患者都患有巴雷特食管。尽管这种化生转变似乎是食管癌流行病学变化的一个主要因素，但它并不是食管鳞状细胞癌向腺癌转变的唯一解释。
