Bansal A S, Haeney M R, Cochrane S, Pumphrey R S, Green L M, Bhavnani M, Wilson P B
Regional Department of Immunology, St Mary's Hospital, Manchester, UK.
Clin Exp Immunol. 1994 Aug;97(2):239-41. doi: 10.1111/j.1365-2249.1994.tb06074.x.
Serum levels of the soluble form of the low-affinity receptor for IgE (FcERII, CD23) (sCD23) are elevated in autoimmune conditions associated with hypergammaglobulinaemia and B cell hyperactivity. Very high levels of sCD23 are found in patients with B-chronic lymphatic leukaemia (B-CLL) who are, however, frequently hypogammaglobulinaemic. We therefore compared the serum levels of sCD23 in healthy controls (n = 33) with three conditions associated with hypogammaglobulinaemia (HGG) and varying B cell numbers: X-linked agammaglobulinaemia (XLA, n = 12), common variable immunodeficiency (CVI, n = 20) and B-chronic lymphatic leukaemia (n = 33). Serum levels of sCD23 showed a significant correlation with the CD19+ B cell count in both normals and patients with CVI (r = 0.65, P < 0.0001). Amongst the different clinical groups, serum levels of sCD23 were increased in the order XLA < CVI < normals < CLL (medians 2.5, 7.7, 11.1 and 540, respectively; P < 0.001 for all comparisons except CVI versus normals P < 0.03 in a one-tailed test). In the CVI group, serum sCD23 was lowest amongst four patients with low B cell numbers. There was no overlap in sCD23 between patients with XLA and this subgroup of CVI patients. Serum sCD23 is, therefore, derived predominantly from B cells, and is significantly related to the peripheral blood B cell count.
在与高丙种球蛋白血症和B细胞功能亢进相关的自身免疫性疾病中，免疫球蛋白E低亲和力受体（FcERII，CD23）的可溶性形式（sCD23）的血清水平会升高。在B细胞慢性淋巴细胞白血病（B-CLL）患者中发现sCD2水平非常高，然而这些患者经常出现低丙种球蛋白血症。因此，我们比较了健康对照组（n = 33）与三种与低丙种球蛋白血症（HGG）及不同B细胞数量相关的疾病中的sCD23血清水平：X连锁无丙种球蛋白血症（XLA，n = 12）、常见变异型免疫缺陷（CVI，n = 20）和B细胞慢性淋巴细胞白血病（n = 33）。sCD23的血清水平在正常人和CVI患者中均与CD19 + B细胞计数呈显著相关性（r = 0.65，P < 0.0001）。在不同的临床组中，sCD23的血清水平按以下顺序升高：XLA < CVI < 正常人 < CLL（中位数分别为2.5、7.7、11.1和540；除CVI与正常人比较，单尾检验P < 0.03外，所有比较P < 0.001）。在CVI组中，B细胞数量低的四名患者的血清sCD23最低。XLA患者与该CVI患者亚组的sCD23没有重叠。因此，血清sCD23主要来源于B细胞，并且与外周血B细胞计数显著相关。
