Lager W, von Lucadou I, Nischik H, Nowak T, Preidel W, Ruprecht L, Stanzel M J, Tegeder V
Corporate Research and Development, Siemens AG, Erlangen, Germany.
Int J Artif Organs. 1994 Mar;17(3):183-8.
A catheter shaped electrocatalytic glucose sensor for in vivo application has been developed to determine the glucose level in blood and control the insulin dosage in a closed loop system for diabetes therapy. The principle of measurement is based on the electrochemical oxidation of glucose at a membrane-covered platium electrode. For various potential steps, the impedance obtained at two different frequencies is a function of the glucose concentration. A series of implantations in the vena cava of sheep demonstrated the potential feasibility of the sensor. It was possible to determine the glucose concentration in sheep for more than 130 days with tolerable deviations from glucose reference measurements. The mean error was 2.5 mmol/l. The catheter was explanted after 211 days and histological examination revealed a good biocompatibility of all materials used.
一种用于体内应用的导管式电催化葡萄糖传感器已被开发出来，用于测定血液中的葡萄糖水平，并在糖尿病治疗的闭环系统中控制胰岛素剂量。测量原理基于葡萄糖在膜覆盖的铂电极上的电化学氧化。对于各种电位阶跃，在两个不同频率下获得的阻抗是葡萄糖浓度的函数。在绵羊腔静脉中的一系列植入证明了该传感器的潜在可行性。能够在超过130天的时间里测定绵羊体内的葡萄糖浓度，与葡萄糖参考测量值的偏差在可容忍范围内。平均误差为2.5 mmol/l。211天后取出导管，组织学检查显示所用所有材料具有良好的生物相容性。
