Griffiss J M
J Immunol. 1975 Jun;114(6):1779-84.
Humoral IgA, separated and purified from human sera drawn 12, 27, and 33 days after infection with serogroups B, Y, and C meningococci, respectively, has been shown to inhibit complement-mediated bacteriolysis by IgG and IgM purified from the same sera. Inhibition was dependent on the ratio of lytic to blocking antibody, was strain specific, and was greater for IgG than IgM. IgM was found to be more active than IgG in a bactericidal test. Activity of IgA appeared unrelated to the presence of a prozone in the whole serum. Similar inhibition was noted for IgA separated from rabbit sera.
分别从感染B、Y和C群脑膜炎球菌后12天、27天和33天采集的人血清中分离纯化得到的体液性IgA，已被证明可抑制从同一血清中纯化得到的IgG和IgM介导的补体依赖性细菌溶解。抑制作用取决于溶菌抗体与阻断抗体的比例，具有菌株特异性，且对IgG的抑制作用大于IgM。在杀菌试验中发现IgM比IgG更具活性。IgA的活性似乎与全血清中前带的存在无关。从兔血清中分离得到的IgA也观察到类似的抑制作用。
