Gordon P M, Goss F L, Visich P S, Warty V, Denys B J, Metz K F, Robertson R J
Human Energy Research Laboratory, University of Pittsburgh, PA.
Med Sci Sports Exerc. 1994 Jun;26(6):671-7. doi: 10.1249/00005768-199406000-00003.
To determine whether exercise intensity influences acute HDL-C responses, 12 male recreational runners (24.8 +/- 4 yr) who ran 15-30 miles.wk-1 exercised on a motor driven treadmill at 60% (L) and 75% (H) VO2max. A counterbalanced experimental design was utilized and energy expenditure was 800 Kcal. Fasting blood samples were obtained 24 h before exercise (24 PRE), immediately post-(IPE), 1 h post- (1 h PE), 6 h post- (6 h PE), and 24 h post- (24 h PE) exercise and analyzed for HDL-C and HDL2&3-C. In addition, postheparin plasma samples, obtained 24 h PRE, 6 h PE, and 24 h PE were analyzed for lipolytic activity--LPLA and HTGLA. An exercise trial by time interaction was observed for HDL-C (P < 0.01). Post-hoc analysis revealed no change in HDL-C following the L trial. However, an increase in HDL-C was observed 24 h PE (P < 0.01) following the H trial. The increase in HDL-C was attributed to an elevated HDL3-C (P < 0.01), with no change in HDL2-C. Analysis of plasma lipolytic activity revealed an increase in LPLA 24 h PE (P < 0.05) which may be responsible for the postexercise alterations in HDL-C. However, HTGLA decreased 6 h PE (P < 0.01) and 24 h PE (P < 0.05). We conclude that increases in HDL-C levels following endurance activity are influenced, in part, by the exercise intensity.
为了确定运动强度是否会影响高密度脂蛋白胆固醇（HDL-C）的急性反应，12名每周跑步15 - 30英里的男性业余跑步者（24.8±4岁）在电动跑步机上以60%（低强度，L）和75%（高强度，H）的最大摄氧量（VO2max）进行运动。采用了平衡实验设计，能量消耗为800千卡。在运动前24小时（24 PRE）、运动后即刻（IPE）、运动后1小时（1小时PE）、运动后6小时（6小时PE）和运动后24小时（24小时PE）采集空腹血样，分析HDL-C以及HDL2&3-C。此外，对运动前24小时、运动后6小时和运动后24小时采集的肝素后血浆样本进行脂解活性分析——脂蛋白脂肪酶活性（LPLA）和肝甘油三酯脂肪酶活性（HTGLA）。观察到HDL-C存在运动试验与时间的交互作用（P < 0.01）。事后分析显示，低强度（L）试验后HDL-C无变化。然而，高强度（H）试验后运动后24小时观察到HDL-C升高（P < 0.01）。HDL-C的升高归因于HDL3-C升高（P < 0.01），而HDL2-C无变化。血浆脂解活性分析显示，运动后24小时LPLA升高（P < 0.05），这可能是运动后HDL-C变化的原因。然而，运动后6小时（P < 0.01）和运动后24小时（P < 0.05）HTGLA降低。我们得出结论，耐力运动后HDL-C水平的升高部分受运动强度影响。
