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天然产物作为药物。

Natural products as drugs.

作者信息

Phillipson J D

机构信息

Department of Pharmacognosy, School of Pharmacy, London, UK.

出版信息

Trans R Soc Trop Med Hyg. 1994 Jun;88 Suppl 1:S17-9. doi: 10.1016/0035-9203(94)90464-2.

Abstract

Higher plants, many of which are threatened with extinction, are used as sources of pharmaceuticals and as ingredients of traditional medicines and are of value in new drug discovery. Artemisinin, taxol and camptothecin are examples of natural products which are undergoing clinical and commercial development. Several natural products isolated from plants used in traditional medicine have potent antiplasmodial action in vitro and represent potential sources of new antimalarial drugs. Plant biotechnology offers the possibility of improved production methods of cultivated medicinal plants as well as alternative approaches to the production of natural products for the preparation of pharmaceuticals.

摘要

许多高等植物正面临灭绝威胁,它们被用作药物来源、传统药物成分,在新药研发中具有重要价值。青蒿素、紫杉醇和喜树碱都是正在进行临床和商业开发的天然产物实例。从传统药用植物中分离出的几种天然产物在体外具有强大的抗疟作用,是新型抗疟药物的潜在来源。植物生物技术为改进栽培药用植物的生产方法以及为制药制备天然产物提供了替代途径。

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