Kemppainen R J, Clark T P
Department of Physiology and Pharmacology, Auburn University College of Veterinary Medicine, Alabama.
Vet Clin North Am Small Anim Pract. 1994 May;24(3):467-76. doi: 10.1016/s0195-5616(94)50052-4.
Hypothyroidism in dogs usually results from a progressive destruction of the thyroid, associated with either lymphocytic thyroiditis or idiopathic atrophy. Both syndromes seem to occur with approximately equal frequency. Lymphocytic thyroiditis, which resembles Hashimoto's thyroiditis in humans, is probably an autoimmune disease, and patients often show thyroid autoantibody titers in circulation. By contrast, the pathogenesis of idiopathic atrophy is unclear, and the thyroid seems simply replaced by adipose and connective tissue.
犬甲状腺功能减退通常是由甲状腺的进行性破坏引起的，与淋巴细胞性甲状腺炎或特发性萎缩有关。这两种综合征的发生率似乎大致相同。淋巴细胞性甲状腺炎类似于人类的桥本甲状腺炎，可能是一种自身免疫性疾病，患病动物的循环系统中常出现甲状腺自身抗体滴度。相比之下，特发性萎缩的发病机制尚不清楚，甲状腺似乎只是被脂肪和结缔组织所取代。
