Gosselin S J, Capen C C, Martin S L
Vet Pathol. 1981 May;18(3):299-309. doi: 10.1177/030098588101800302.
Thyroid lesions in 16 pet dogs with hypothyroidism were evaluated by light and electron microscopy. Lymphocytic thyroiditis, found in seven dogs, was characterized by diffuse infiltration of the thyroid gland by lymphocytes, plasma cells and macrophages with formation of some lymphoid nodules and destruction of follicles, progressing to replacement of most of the thyroid by fibrous connective tissue. The basement membrane around follicles was thick and had electron-dense deposits. The morphology of the thyroid lesions and the presence of circulating thyroglobulin autoantibodies suggested that lymphocytic thyroiditis was immune-mediated. Idiopathic follicular atrophy, found in nine dogs, was characterized by loss of thyroid parenchyma and replacement by adipose connective tissue. Degeneration of individual follicular cells was present in the early stage, with exfoliation into the colloid and interfollicular area. Most of the thyroid gland consisted of adipose connective tissue with either interspersed small follicles or individual follicular cells that had dilated rough endoplasmic reticulum, large Golgi apparatus, and intracytoplasmic microfollicles in the advanced stage. Follicular atrophy was a degenerative lesion of follicular cells of unknown cause, not associated with inflammatory destruction in the thyroid gland.
对16只患甲状腺功能减退症的宠物犬的甲状腺病变进行了光镜和电镜评估。在7只犬中发现淋巴细胞性甲状腺炎，其特征为淋巴细胞、浆细胞和巨噬细胞弥漫性浸润甲状腺，形成一些淋巴小结并破坏滤泡，进而发展为大部分甲状腺被纤维结缔组织取代。滤泡周围的基底膜增厚并有电子致密沉积物。甲状腺病变的形态以及循环甲状腺球蛋白自身抗体的存在提示淋巴细胞性甲状腺炎是免疫介导的。在9只犬中发现特发性滤泡萎缩，其特征为甲状腺实质丧失并被脂肪结缔组织取代。早期个别滤泡细胞出现变性，脱落在胶体和滤泡间区域。在晚期，大部分甲状腺由脂肪结缔组织组成，其间散布着小滤泡或有扩张粗面内质网、大型高尔基体和胞质内微滤泡的单个滤泡细胞。滤泡萎缩是滤泡细胞的一种退行性病变，病因不明，与甲状腺的炎症破坏无关。
