Fitzsimmons L
Crit Care Nurs Q. 1994 Aug;17(2):74-90. doi: 10.1097/00002727-199408000-00008.
Critically injured patients are at risk for systemic inflammatory response syndrome (SIRS) and multiple organ dysfunction syndrome (MODS). MODS is a clinical syndrome of progressive physiologic dysfunction of organ systems. Trauma patients are at high risk for SIRS/MODS because of circulatory shock with tissue hypoxemia, tissue injury, and infection. Organ dysfunction may be a direct consequence of an insult (primary MODS) or may manifest latently (secondary MODS) and involves organs not initially injured. Management of SIRS/secondary MODS requires control/elimination of the source of inflammation, maintenance of tissue oxygenation, nutritional/metabolic support, support for individual organs, and effective pain control.
重症创伤患者有发生全身炎症反应综合征（SIRS）和多器官功能障碍综合征（MODS）的风险。MODS是一种器官系统进行性生理功能障碍的临床综合征。创伤患者因伴有组织低氧血症的循环性休克、组织损伤和感染而发生SIRS/MODS的风险很高。器官功能障碍可能是损伤的直接后果（原发性MODS），也可能潜在表现（继发性MODS），且累及最初未受伤的器官。SIRS/继发性MODS的治疗需要控制/消除炎症源、维持组织氧合、营养/代谢支持、支持单个器官以及有效控制疼痛。
