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异丙酚在体外抑制多形核白细胞对金黄色葡萄球菌和大肠杆菌的吞噬及杀灭作用。

Propofol inhibits phagocytosis and killing of Staphylococcus aureus and Escherichia coli by polymorphonuclear leukocytes in vitro.

作者信息

Krumholz W, Endrass J, Hempelmann G

机构信息

Department of Anaesthesiology and Intensive Care Medicine, Justus-Liebig-University Giessen, Federal Republic of Germany.

出版信息

Can J Anaesth. 1994 May;41(5 Pt 1):446-9. doi: 10.1007/BF03009871.

DOI:10.1007/BF03009871
PMID:8055616
Abstract

Polymorphonuclear leukocytes (PMNL) are important components of the immunological defence system which protects the human organism from invading bacteria. Using a fluorescence microscopic method, we examined the influence of propofol and its solvent intralipid on phagocytosis and killing of Staphylococcus aureus and Escherichia coli by PMNL in vitro. Propofol inhibited (P < or = 0.001) phagocytosis of Staphylococcus aureus as well as Escherichia coli. Killing of Staphylococcus aureus (P < or = 0.001) and of Escherichia coli (P < or = 0.01) was suppressed. Intralipid, by itself, impaired phagocytosis of Escherichia coli (P < or = 0.05). Apart from that, intralipid produced no relevant effects. Additional clinical studies regarding the influence of propofol on PMNL function are recommended.

摘要

多形核白细胞（PMNL）是免疫防御系统的重要组成部分，该系统保护人体免受入侵细菌的侵害。我们采用荧光显微镜法，在体外研究了丙泊酚及其溶剂乳剂对PMNL吞噬和杀灭金黄色葡萄球菌及大肠杆菌的影响。丙泊酚抑制（P≤0.001）金黄色葡萄球菌和大肠杆菌的吞噬作用。金黄色葡萄球菌（P≤0.001）和大肠杆菌（P≤0.01）的杀灭作用受到抑制。乳剂本身会损害大肠杆菌的吞噬作用（P≤0.05）。除此之外，乳剂没有产生相关影响。建议开展关于丙泊酚对PMNL功能影响的更多临床研究。

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