Skoutelis A, Lianou P, Papageorgiou E, Kokkinis K, Alexopoulos K, Bassaris H
Department of Medicine, Patras University, Medical School, Greece.
Acta Anaesthesiol Scand. 1994 Nov;38(8):858-62. doi: 10.1111/j.1399-6576.1994.tb04018.x.
Anesthetic agents may impair host defense mechanisms including polymorphonuclear leukocyte (PMNL) function. We have studied the effects of thiopentone and propofol in low (thiopentone 10 mg/L, propofol 2 mg/l) and high (thiopentone 40 mg/L, propofol 6 mg/L) clinically relevant concentrations on PMNL adherence, chemotaxis, phagocytosis and killing in vitro. The results demonstrated that thiopentone in both concentrations significantly decreases all PMNL functions tested and had a direct influence on the PMNLs in terms of their chemotactic response. In contrast, propofol decreases significantly only PMNL chemotaxis but not adherence, phagocytosis and killing. The effect of propofol was not attributable to the lipid carrier vehicle, as Intralipid with same formulation had no effect on PMNL function. We conclude that propofol is a relatively safe agent from the viewpoint of PMNL function in vitro, which may be of potential clinical benefit.
麻醉剂可能会损害包括多形核白细胞（PMNL）功能在内的宿主防御机制。我们研究了硫喷妥钠和丙泊酚在低（硫喷妥钠10 mg/L，丙泊酚2 mg/l）和高（硫喷妥钠40 mg/L，丙泊酚6 mg/L）临床相关浓度下对体外PMNL黏附、趋化性、吞噬作用和杀伤作用的影响。结果表明，两种浓度的硫喷妥钠均显著降低了所有测试的PMNL功能，并且就其趋化反应而言，对PMNL有直接影响。相比之下，丙泊酚仅显著降低PMNL趋化性，而对黏附、吞噬作用和杀伤作用无影响。丙泊酚的作用并非归因于脂质载体，因为相同配方的脂肪乳剂对PMNL功能无影响。我们得出结论，从体外PMNL功能的角度来看，丙泊酚是一种相对安全的药物，这可能具有潜在的临床益处。
