Nakamura M, Nishida T, Hikida M, Otori T
Department of Ophthalmology, Yamaguchi University School of Medicine, Japan.
Curr Eye Res. 1994 May;13(5):385-8. doi: 10.3109/02713689409167303.
We investigated the combined effects of hyaluronan and fibronectin on corneal epithelial wound closure in vivo. When fibronectin eye drops (1 mg/ml) were administered for the first 4 hours after chemical cautery and hyaluronan eye drops (1 mg/ml) were administered for following 32 hours, the mean healing rate was significantly higher than in control eyes treated with phosphate buffered saline instead of fibronectin or with initial fibronectin alone. These results demonstrated that hyaluronan and fibronectin have a synergistic effect, with fibronectin pretreatment augmenting hyaluronan-stimulated corneal epithelial wound closure.
我们研究了透明质酸和纤连蛋白对体内角膜上皮伤口愈合的联合作用。在化学烧灼后的前4小时给予纤连蛋白滴眼液（1mg/ml），随后32小时给予透明质酸滴眼液（1mg/ml），其平均愈合率显著高于用磷酸盐缓冲盐水代替纤连蛋白处理的对照眼或仅初始给予纤连蛋白的对照眼。这些结果表明，透明质酸和纤连蛋白具有协同作用，纤连蛋白预处理可增强透明质酸刺激的角膜上皮伤口愈合。
