Ventura M T, Serlenga E, Tortorella C, Antonaci S
Istituto di Medicina Clinica, University of Bari Medical Faculty, Italy.
Cytobios. 1994;77(311):225-32.
The in vitro effects of vitamin E and selenium on either polymorphonuclear cell (PMN)-mediated chemotaxis and phagocytosis or monocyte chemoattractant protein-1 (MCP-1) production in 21 well-nourished elderly donors were evaluated. Results show that, before treatment, old subjects were characterized by a decrease of both PMN functions and cytokine (CK) release. By contrast, in vitro vitamin E and selenium supplementation was able to enhance significantly the depressed PMN activities and MCP-1 synthesis. These findings suggest a role for both nutrients in the modulation of impaired phagocyte responsiveness during senescence.
评估了维生素E和硒对21名营养良好的老年捐赠者的多形核细胞（PMN）介导的趋化性和吞噬作用或单核细胞趋化蛋白-1（MCP-1）产生的体外影响。结果显示，在治疗前，老年受试者的特征是PMN功能和细胞因子（CK）释放均下降。相比之下，体外补充维生素E和硒能够显著增强PMN活性和MCP-1合成的降低。这些发现表明这两种营养素在衰老过程中调节受损吞噬细胞反应性方面具有作用。
