Wintersberger E
Institut für Molekularbiologie, Universität Wien, Austria.
Chromosoma. 1994 Apr;103(2):73-81. doi: 10.1007/BF00352315.
DNA amplification is a process whereby a limited part of the genome is increased in copy number with various consequences for the cell. It is frequently observed in cancer cells and it can be induced in mammalian cells grown in culture as well as in tumor cells when these are subjected to growth inhibiting drugs. In recent years new insights into the mechanisms involved in DNA amplification have been obtained; discussion of these will form the major subject of this short review.
DNA扩增是一个过程，通过这个过程基因组的有限部分拷贝数增加，对细胞产生各种影响。它在癌细胞中经常被观察到，并且当培养的哺乳动物细胞以及肿瘤细胞受到生长抑制药物作用时也可被诱导产生。近年来，人们对DNA扩增所涉及的机制有了新的认识；对这些机制的讨论将构成本简短综述的主要主题。
