Dalton S
Department of Biochemistry, University of Adelaide, South Australia, Australia.
Immunol Cell Biol. 1998 Oct;76(5):467-72. doi: 10.1046/j.1440-1711.1998.00777.x.
Accurate replication and segregation of chromosomal DNA is essential for high-fidelity transmission of genetic information from generation to generation. Eukaryotic cells typically replicate by first duplicating their chromosomes during the S phase followed by their segregation between two daughter cells during the M phase. Over recent years, advances in our understanding of this process at the molecular level have been incredibly rapid. The present review will focus on molecular control of DNA replication and the mechanisms which operate to ensure that once replicated, chromosomes are not rereplicated in the same cell cycle.
染色体DNA的准确复制和分离对于遗传信息在世代间的高保真传递至关重要。真核细胞通常通过在S期首先复制其染色体，然后在M期将其在两个子细胞之间进行分离来进行复制。近年来，我们对这一过程在分子水平上的理解取得了惊人的快速进展。本综述将聚焦于DNA复制的分子控制以及确保一旦复制，染色体不会在同一细胞周期中再次复制的运作机制。
