Schuckit M A
Arch Gen Psychiatry. 1984 Sep;41(9):879-84. doi: 10.1001/archpsyc.1984.01790200061008.
We matched 23 nonalcoholic male drinkers who were aged 21 to 25 years and had alcoholic close relatives (FHP) with 23 control subjects with negative family histories (FHN) for demographic characteristics and drinking and smoking histories. The subjective feelings of intoxication for the 46 men were studied on three occasions using placebo, 0.75 mL/kg of ethanol, and 1.1 mL/kg of ethanol. The FHP subjects (at elevated risk for the development of alcoholism) reported less intense feelings of subjective intoxication after drinking, especially during the two hours following the peak blood alcohol concentration (BAC). Group differences were most marked with the 0.75-mL/kg dose. The two groups did not differ significantly on their BACs nor on the expectation of how they would feel under the influence of alcohol.
我们将23名年龄在21至25岁之间、有酗酒近亲（FHP）的非酒精性男性饮酒者与23名无家族酗酒史（FHN）的对照受试者在人口统计学特征、饮酒和吸烟史方面进行了匹配。对这46名男性的主观醉酒感受分三次进行了研究，分别使用安慰剂、0.75 mL/kg乙醇和1.1 mL/kg乙醇。FHP受试者（患酒精中毒风险较高）饮酒后报告的主观醉酒感受较弱，尤其是在血液酒精浓度（BAC）达到峰值后的两小时内。在0.75-mL/kg剂量下，两组差异最为明显。两组在BAC以及对饮酒后感觉的预期方面没有显著差异。
