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[I型和II型糖尿病患者的循环免疫复合物]

[Circulating immune complexes in patients with diabetes type I and II].

作者信息

Jabłońska E, Pietruska Z

机构信息

Zakład Immunopatologii, Klinika Endokrynologii AM, Białymstoku.

出版信息

Endokrynol Pol. 1993;44(2):129-35.

PMID:8055783
Abstract

The relation between the concentration of immunocomplexes and the number of granulocytes having the surface receptors for Fc immunoglobulin fragment and for C3 component of complement was studied in diabetic patients. The concentration of immunocomplexes was determined with the precipitation method of Swierczyńska or with the method of rosette blocking according to Pazdur et al. The expression of the granulocytic receptors was evaluated by using the modified rosette EA and EAC method according to Buesher. An increase in the concentration of immunocomplexes and a decrease in the percentage of granulocytes having the surface receptors for Fc fragment and C3 protein have been observed in patients with type I and type II diabetes. No correlation was found between the concentration of immunocomplexes and the number of cells with receptors for Fc immunoglobulin fragment and C3 component of complement.

摘要

对糖尿病患者免疫复合物浓度与具有免疫球蛋白Fc片段表面受体和补体C3成分表面受体的粒细胞数量之间的关系进行了研究。免疫复合物浓度采用斯维琴斯卡沉淀法或根据帕兹杜尔等人的玫瑰花环阻断法测定。采用根据布舍尔改良的玫瑰花环EA和EAC法评估粒细胞受体的表达。在I型和II型糖尿病患者中均观察到免疫复合物浓度升高,以及具有Fc片段和C3蛋白表面受体的粒细胞百分比降低。未发现免疫复合物浓度与具有免疫球蛋白Fc片段受体和补体C3成分的细胞数量之间存在相关性。

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