Gilly F N, Carry P Y, Sayag A C, Brachet A, Panteix G, Salle B, Bienvenu J, Burgard G, Guibert B, Banssillon V
Department of General and Thoracic Surgery, Centre Hospitalier Lyon Sud, France.
Hepatogastroenterology. 1994 Apr;41(2):124-9.
Intraperitoneal chemo-hyperthermia with mitomycin C was used to treat 28 patients with far advanced digestive adenocarcinoma and histologically confirmed peritoneal carcinomatosis. Surgical resection of the primary tumor was possible in 17 cases. After closure of the abdominal wall, intraperitoneal chemo-hyperthermia was performed for 90 to 120 minutes under general anesthesia and 32 degrees C hypothermia, through 3 intraperitoneal drains forming a closed circuit, using 10 mg/l of mitomycin C in 6 liters of peritoneal dialysate heated to an inflow temperature of 46-49 degrees C. No mortality occurred, and there were 2 post-operative complications, with transitory biological side effects. In 9 out of 10 patients with preoperative malignant ascites, the ascites cleared after treatment. One-year survival rate was 54.2%. These encouraging preliminary results show that intraperitoneal chemohyperthermia with mitomycin C is a safe and reliable treatment for peritoneal carcinomatosis in far advanced digestive cancers.
采用丝裂霉素C腹腔内热化疗治疗28例晚期消化腺癌且经组织学证实有腹膜癌转移的患者。17例患者可行原发性肿瘤手术切除。关闭腹壁后，在全身麻醉和32℃低温下，通过3根形成闭合回路的腹腔引流管，在6升加热至流入温度46 - 49℃的腹膜透析液中使用10mg/l丝裂霉素C，进行90至120分钟的腹腔内热化疗。无死亡病例，术后有2例并发症，伴有短暂的生物学副作用。10例术前有恶性腹水的患者中，9例治疗后腹水消退。1年生存率为54.2%。这些令人鼓舞的初步结果表明，丝裂霉素C腹腔内热化疗是晚期消化癌腹膜癌转移的一种安全可靠的治疗方法。
