Salle B, Gilly F N, Carry P Y, Sayag A, Brachet A, Braillon G
Service de chirurgie B, Centre Hospitalier Lyon Sud, Saint-Genis-Laval.
J Gynecol Obstet Biol Reprod (Paris). 1993;22(4):369-71.
The authors report the first results using intraperitoneal hyperthermic chemotherapy with mitomycin C or cisplatinum with protective hypothermia up to 32 degrees C in four cases of peritoneal carcinomatosis secondary to cancer of the ovary which was resistant to conventional treatment. They were stage III and IV in the FIGO classification. There were no post-operative complications. Two patients are still alive 4 and 6 months after intraperitoneal hyper-chemotherapy. Hypothermia has its own action of destroying tumour cells and potentiates the effects of chemotherapy. We have, following the work of the japanese, devised a therapeutic regime combining chemotherapy and intraperitoneal hyperthermia.
作者报告了首例对4例卵巢癌继发腹膜癌病患者采用腹腔内热化疗联合丝裂霉素C或顺铂及高达32摄氏度的保护性低温治疗的结果，这些患者对传统治疗耐药。根据国际妇产科联盟（FIGO）分类，他们处于III期和IV期。术后无并发症。两名患者在腹腔内热化疗后分别存活了4个月和6个月。低温有其自身破坏肿瘤细胞的作用，并能增强化疗效果。我们借鉴日本人的研究成果，设计了一种化疗与腹腔内热疗相结合的治疗方案。
