Judd F K, Mijch A M, Cockram A, Norman T R
Fairfield Infectious Diseases Hospital, Australia.
Int Clin Psychopharmacol. 1994 Summer;9(2):123-5.
The antituberculous drug isoniazid has weak monoamine oxidase inhibiting properties. Drug and dietary restrictions generally applied to the use of monoamine oxidase inhibitors (MAOI) have not been routinely recommended with its use. Here we report three cases in which antidepressant drugs and isoniazid were co-administered. In two, adverse events, possibly due to an interaction between the drugs prescribed are described. We suggest that the combination of isoniazid and antidepressants be used with caution until further data are accumulated.
抗结核药物异烟肼具有较弱的单胺氧化酶抑制特性。一般应用于单胺氧化酶抑制剂（MAOI）使用的药物和饮食限制，在使用异烟肼时并未常规推荐。在此我们报告三例同时使用抗抑郁药物和异烟肼的病例。其中两例描述了可能由于所开药物之间相互作用导致的不良事件。我们建议，在积累更多数据之前，应谨慎使用异烟肼和抗抑郁药物的联合用药。
