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Isoniazid, tricyclics and the "cheese reaction".

作者信息

DiMartini A

机构信息

Western Psychiatric Institute and Clinic, Pittsburgh, PA 15213, USA.

出版信息

Int Clin Psychopharmacol. 1995 Sep;10(3):197-8. doi: 10.1097/00004850-199510030-00009.

DOI:10.1097/00004850-199510030-00009
PMID:8675973
Abstract

Isoniazid is an antitubercular drug with some monamine oxidase (MAO) inhibition. Perhaps because this is only weak inhibition, a few clinicians consider dietary or drug restrictions for their patients on isoniazid. However recent reports suggest the combination of isoniazid and antidepressants may cause adverse events possibly related to isoniazid's MAO inhibition activity. The mechanism of the tyramine reaction and recommendations for cautious combinations of tricyclic antidepressants and isoniazid are discussed.

摘要

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An evaluation of potential mechanism-based inactivation of human drug metabolizing cytochromes P450 by monoamine oxidase inhibitors, including isoniazid.
对包括异烟肼在内的单胺氧化酶抑制剂基于潜在机制使人药物代谢细胞色素P450失活的评估。
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