基于结构的嘌呤核苷磷酸化酶抑制剂设计。5. 9-脱氮次黄嘌呤。
Structure-based design of inhibitors of purine nucleoside phosphorylase. 5. 9-Deazahypoxanthines.
作者信息
Niwas S, Chand P, Pathak V P, Montgomery J A
机构信息
Southern Research Institute, Birmingham, Alabama 35255-5305.
出版信息
J Med Chem. 1994 Jul 22;37(15):2477-80. doi: 10.1021/jm00041a027.
PMID:8057293
Abstract
The synthesis and evaluation as inhibitors of purine nucleoside phosphorylase of six 9-deazahypoxanthines (2a-f) are reported. In contrast to reports in the literature of other hypoxanthine-guanine analog pairs, these inhibitors (2a-f) are equipotent with the corresponding 9-deazaguanines.
摘要
报道了六种9-脱氮次黄嘌呤（2a - f）作为嘌呤核苷磷酸化酶抑制剂的合成及评估。与文献中关于其他次黄嘌呤 - 鸟嘌呤类似物对的报道不同，这些抑制剂（2a - f）与相应的9-脱氮鸟嘌呤具有同等效力。
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