Pekarek R S, Hauer E C, Rayfield E J, Wannemacher R W, Beisel W R
Diabetes. 1975 Apr;24(4):350-3. doi: 10.2337/diab.24.4.350.
Studies in healthy individuals demonstrate that serum chromium concentrations fall precipitiously following the intravenous administration of a 30-gm. glucose load. Significant decreases from baseline control fasting serum Cr concentrations were also observed when intravenous glucose was given during sandfly fever. Glucose disappearance rates also decreased significantly to approximately one half of pre-illness control values while serum Cr values declined still further. In addition, serum Cr disappearance rates could be calculated. When individual preexposure and postexposure serum glucose and Cr disappearance rates were compared, significant linear correlation was found (P smaller than 0.05). Acute infection appears to reduce the availability of circulating Cr, which may contribute to the altered glucose metabolism characteristic of acute infections even in the presence of elevated insulin levels and other hormonal changes.
对健康个体的研究表明，静脉注射30克葡萄糖负荷后，血清铬浓度会急剧下降。在白蛉热期间静脉注射葡萄糖时，也观察到空腹血清铬浓度较基线对照有显著下降。葡萄糖消失率也显著降低至患病前对照值的约一半，而血清铬值则进一步下降。此外，还可以计算血清铬消失率。当比较个体暴露前和暴露后血清葡萄糖和铬的消失率时，发现存在显著的线性相关性（P小于0.05）。急性感染似乎会降低循环铬的可用性，这可能导致即使在胰岛素水平升高和其他激素变化的情况下，急性感染所特有的葡萄糖代谢改变。
