Anderson R A, Polansky M M, Bryden N A, Roginski E E, Mertz W, Glinsmann W
Metabolism. 1983 Sep;32(9):894-9. doi: 10.1016/0026-0495(83)90203-2.
Seventy-six normal, free-living subjects were given supplements of 200 micrograms chromium (Cr) in the form of chromic chloride or a placebo in a double-blind crossover study with 3-month experimental periods. Twenty of the 76 subjects had serum glucose concentrations greater than or equal to 100 mg/dL 90 minutes after a glucose challenge (1 g glucose per kilogram of body weight). Chromium supplementation significantly decreased (P less than 0.05) the 90-minute glucose concentration of these subjects from 135 +/- 9 to 116 +/- 11 mg/dL; fasting glucose concentrations also decreased significantly. The 90-minute serum glucose levels of the 35 subjects with glucose concentrations less than the fasting serum glucose level were increased significantly by Cr supplementation, from 71 +/- 1 to 81 +/- 4 mg/dL. Fasting and 90-minute serum glucose concentrations of the remaining subjects who displayed 90-minute glucose concentrations greater than fasting levels but less than 100 mg/dL were not affected by Cr supplementation. In this study, immunoreactive serum insulin concentration, body weight, lipids, and other selected clinical variables did not change significantly during Cr supplementation. These data demonstrate that Cr supplementation decreases the serum glucose levels of subjects with 90-minute glucose concentrations greater than or equal to 100 mg/dL following a glucose challenge, increases serum glucose levels of subjects with 90-minute glucose concentrations less than fasting levels, and has no effect on the serum glucose levels of subjects with 90-minute glucose values similar to but greater than fasting levels.
在一项为期3个月试验期的双盲交叉研究中，76名正常的自由生活受试者被给予200微克氯化铬形式的铬（Cr）补充剂或安慰剂。76名受试者中有20人在葡萄糖激发试验（每千克体重1克葡萄糖）后90分钟时血清葡萄糖浓度大于或等于100毫克/分升。补充铬显著降低了（P<0.05）这些受试者90分钟时的葡萄糖浓度，从135±9降至116±11毫克/分升；空腹血糖浓度也显著降低。对于35名90分钟时葡萄糖浓度低于空腹血清葡萄糖水平的受试者，补充铬使其90分钟时的血清葡萄糖水平显著升高，从71±1升至81±4毫克/分升。其余90分钟时葡萄糖浓度高于空腹水平但低于100毫克/分升的受试者，其空腹和90分钟时的血清葡萄糖浓度在补充铬期间未受影响。在本研究中，补充铬期间免疫反应性血清胰岛素浓度、体重、血脂及其他选定的临床变量未发生显著变化。这些数据表明，补充铬可降低葡萄糖激发试验后90分钟时葡萄糖浓度大于或等于100毫克/分升的受试者的血清葡萄糖水平，升高90分钟时葡萄糖浓度低于空腹水平的受试者的血清葡萄糖水平，而对90分钟时葡萄糖值高于空腹水平但低于100毫克/分升的受试者的血清葡萄糖水平无影响。
