Shukla V K, Shukla P K, Pandey M, Rao B R, Roy S K
University Department of Surgery, Banaras Hindu University, Varanasi, India.
J Surg Oncol. 1994 Aug;56(4):258-62. doi: 10.1002/jso.2930560415.
Samples of gall bladder bile from patients with and without carcinoma of the gallbladder were examined for lipid peroxidation (free radical oxidation) products. 4-hydroxynonenal (HNE) was found in higher concentration in the bile of patients with carcinoma of the gall bladder. There was also a highly significant difference in the concentration of HNE among carcinoma of the gall bladder, cholelithiasis and control group of patients with miscellaneous abdominal disorders. This is the first study of lipid peroxidation in carcinoma of the gall bladder.
对患有和未患有胆囊癌的患者的胆囊胆汁样本进行脂质过氧化（自由基氧化）产物检测。发现4-羟基壬烯醛（HNE）在胆囊癌患者胆汁中的浓度更高。胆囊癌、胆结石患者以及患有各种腹部疾病的对照组患者之间，HNE浓度也存在极显著差异。这是首次对胆囊癌中的脂质过氧化进行研究。
