Marks M P, Chee H, Liddell R P, Steinberg G K, Panahian N, Lane B
Department of Radiology, Stanford University Medical Center, CA 94305-5105.
AJNR Am J Neuroradiol. 1994 May;15(5):821-7.
To evaluate mechanically detachable coil designs capable of controlled and instantaneous release within an aneurysm or vascular space.
Three mechanically detachable coil designs, clamped ball, looped ribbon, and interlocking cylinder, were evaluated using in vitro and in vivo testing to study reliability of coil release, retractability, and coil behavior in a microcatheters. In vitro tests were performed using a glass side-wall aneurysm model and conventional microcatheters. In vivo experiments in rabbits included aneurysm models (side-wall and bifurcation) and arterial occlusions (carotid and renal).
All three designs deployed coils easily and were able to retract coils after partial deployment. Motion was seen in previously released coils and in the catheter when using the clamped ball and looped ribbon designs. The interlocking cylinder design did not cause similar motion. When compared with the other two designs, the interlocking cylinder had significantly greater separation forces between coil pusher and coil while in the catheter. Frictional forces within the catheter were lower for the interlocking cylinder mechanically detachable coil design than for a commercially available conventional coil and coil pusher system. During in vivo testing, the mechanically detachable coil design operated smoothly in the catheter, providing good release and retraction in aneurysms and straight vessels.
The interlocking cylinder mechanically detachable coil design is superior to the other two tested designs. The mechanically detachable coil was reliably delivered and detached in in vivo testing for the treatment of aneurysms and for the occlusion of blood vessels.
评估能够在动脉瘤或血管腔内实现可控即时释放的机械可脱卸线圈设计。
使用体外和体内测试对三种机械可脱卸线圈设计（夹球式、环形带式和联锁圆筒式）进行评估，以研究线圈释放的可靠性、可回缩性以及在微导管中的线圈行为。体外测试使用玻璃侧壁动脉瘤模型和传统微导管进行。在兔体内进行的实验包括动脉瘤模型（侧壁和分叉处）和动脉闭塞（颈动脉和肾动脉）。
所有三种设计都能轻松展开线圈，并且在部分展开后能够回缩线圈。使用夹球式和环形带式设计时，先前释放的线圈以及导管中均可见运动。联锁圆筒式设计未引起类似运动。与其他两种设计相比，联锁圆筒式在导管内时，线圈推送器与线圈之间的分离力明显更大。联锁圆筒式机械可脱卸线圈设计在导管内的摩擦力低于市售传统线圈和线圈推送器系统。在体内测试期间，机械可脱卸线圈设计在导管中操作顺畅，在动脉瘤和直血管中实现了良好的释放和回缩。
联锁圆筒式机械可脱卸线圈设计优于其他两种测试设计。在用于治疗动脉瘤和闭塞血管的体内测试中，机械可脱卸线圈能够可靠地输送和脱卸。
