Kasatkina I V, Sherbaniuk A I, Makarovskaia L N, Padeĭskaia E N
Antibiot Khimioter. 1993 Jan;38(1):42-5.
Efficacy of ciprofloxacin and pefloxacin in plague infection was studies on albino mice by comparison with that of nalidixic acid. The mice were contaminated subcutaneously. The treatment with the drugs was started 6 or 24 hours after the contamination. The MICs of ciprofloxacin, pefloxacin and nalidixic acid were 0.01 to 0.02, 0.15 and 1.25 to 2.5 micrograms/ml respectively. By the ED50 ciprofloxacin proved to be the most efficient. Pefloxacin was 6 times less efficient and nalidixic acid was 100 times less efficient. The quinolones were shown to be highly efficient when administered at 48-hour intervals.
通过与萘啶酸比较，研究了环丙沙星和培氟沙星对白化病小鼠鼠疫感染的疗效。小鼠经皮下感染。在感染后6或24小时开始用药物治疗。环丙沙星、培氟沙星和萘啶酸的最低抑菌浓度分别为0.01至0.02、0.15和1.25至2.5微克/毫升。通过半数有效剂量证明环丙沙星效率最高。培氟沙星的效率低6倍，萘啶酸的效率低100倍。喹诺酮类药物以48小时间隔给药时显示出高效。
