Cigolini M, Targher G, Seidell J C, Schiavon R, Manara F, Zenti M G, Mattioli C, De Sandre G
Institute of Clinical Medicine, University of Verona, Italy.
Atherosclerosis. 1994 Apr;106(2):139-47. doi: 10.1016/0021-9150(94)90119-8.
Increased plasma levels of plasminogen activator inhibitor-1 (PAI-1), responsible for reduced fibrinolytic activity, have been shown to be an important risk factor for cardiovascular disease. PAI-1 plasma levels are influenced by several factors which have not yet been fully clarified, including dietary fat intake. The relationships of PAI-1 with other cardiovascular risk factors are still not well known. In a random sample of 38-year-old healthy men (n = 94), the association of PAI-1 plasma levels (measured as activity and antigen) with anthropometric parameters, serum lipids, fasting and 2 h insulin and glucose concentration after oral glucose-load was analysed. Furthermore, the fatty acid composition of subcutaneous adipose tissue, as an objective and reliable index of dietary fat intake, was measured. The univariate analysis showed that plasma levels of PAI-1 were significantly associated with body mass index (BMI) (r = 0.37, P < 0.001), waist/hip ratio (WHR) (r = 0.26, P < 0.01), serum triglycerides (r = 0.47, P < 0.0001), HDL/total cholesterol ratio (r = -0.35, P < 0.001), fasting and 2-h insulin (r = 0.27, P < 0.01 and r = 0.34, P < 0.001) and glucose concentrations (r = 0.25, P < 0.05 and r = 0.28, P < 0.01).(ABSTRACT TRUNCATED AT 250 WORDS)
纤溶酶原激活物抑制剂-1（PAI-1）血浆水平升高会导致纤溶活性降低，已被证明是心血管疾病的一个重要危险因素。PAI-1血浆水平受多种因素影响，其中一些因素尚未完全明确，包括膳食脂肪摄入。PAI-1与其他心血管危险因素之间的关系仍不为人所知。在一个38岁健康男性的随机样本（n = 94）中，分析了PAI-1血浆水平（以活性和抗原形式测量）与人体测量参数、血脂、空腹及口服葡萄糖负荷后2小时胰岛素和葡萄糖浓度之间的关联。此外，还测量了皮下脂肪组织的脂肪酸组成，作为膳食脂肪摄入的客观可靠指标。单因素分析显示，PAI-1血浆水平与体重指数（BMI）（r = 0.37，P < 0.001）、腰臀比（WHR）（r = 0.26，P < 0.01）、血清甘油三酯（r = 0.47，P < 0.0001）、高密度脂蛋白/总胆固醇比值（r = -0.35，P < 0.001）、空腹及2小时胰岛素（r = 0.27，P < 0.01和r = 0.34，P < 0.001）以及葡萄糖浓度（r = 0.25，P < 0.05和r = 0.28，P < 0.01）显著相关。（摘要截选至250字）
