Wilson R D, Farquharson D F, Wittmann B K, Shaw D
Department of Medical Genetics, University of British Columbia, CPDT, Grace Hospital, Vancouver, Canada.
Fetal Diagn Ther. 1994 May-Jun;9(3):142-8. doi: 10.1159/000263922.
A 4-year retrospective review of cordocentesis at a single center with four operators identified 182 patients undergoing 214 cordocenteses. The major indications were chromosomal, fetal platelet and rhesus evaluation. The procedure was successful in 95%. A positive genetic diagnosis was present in 18% with 64% having trisomy 18, 21 or 13. The procedural pregnancy loss rate was 3.25, 1.25 and 2.75% for chromosomal and nonchromosomal indications and total population, respectively. The overall fetal loss rate (procedural, nonprocedural) in chromosomal risk population was 47%. This overall pregnancy loss risk should be included in patient counselling.
对某单一中心由四名操作人员进行的182例患者接受214次脐带穿刺术进行了为期4年的回顾性研究。主要指征为染色体、胎儿血小板和恒河猴血型评估。该操作成功率为95%。18%的患者获得了阳性基因诊断，其中64%为18、21或13三体。染色体和非染色体指征以及总体人群的操作导致的妊娠丢失率分别为3.25%、1.25%和2.75%。染色体风险人群中的总体胎儿丢失率（操作相关、非操作相关）为47%。这种总体妊娠丢失风险应纳入对患者的咨询中。
