Furue M, Sugiyama H, Tsukamoto K, Ohtake N, Tamaki K
Department of Dermatology, Yamanashi Medical University, Japan.
J Dermatol Sci. 1994 Apr;7(2):89-95. doi: 10.1016/0923-1811(94)90081-7.
We examined the serum soluble IL-2 receptor and eosinophil cationic protein levels in patients with atopic dermatitis (n = 21), patients with urticaria (n = 12), and normal healthy individuals (n = 14). We found that both soluble IL-2 receptor levels and eosinophil cationic protein levels were significantly higher in atopic dermatitis than in urticaria or normal controls. Although both soluble IL-2 receptor levels and eosinophil cationic protein levels were significantly correlated with clinical severity scores in atopic dermatitis, the correlation between eosinophil cationic protein levels and clinical severity scores was higher than that between soluble IL-2 receptor levels and clinical severity scores. However, soluble IL-2 receptor levels, eosinophil cationic protein levels and clinical severity scores were not significantly correlated with IgE levels. The chronological changes of soluble IL-2 receptor and eosinophil cationic protein levels differ from patient to patient. However, levels of soluble IL-2 receptor and eosinophil cationic protein seem to parallel to each other in 65% of patients with AD. Measurement of serum eosinophil cationic protein or soluble IL-2 receptor levels may be a useful tool to monitor the short-term or long-term disease activity of atopic dermatitis in conjunction with clinical severity scores.
我们检测了特应性皮炎患者（n = 21）、荨麻疹患者（n = 12）和正常健康个体（n = 14）的血清可溶性白细胞介素-2受体和嗜酸性粒细胞阳离子蛋白水平。我们发现，特应性皮炎患者的可溶性白细胞介素-2受体水平和嗜酸性粒细胞阳离子蛋白水平均显著高于荨麻疹患者或正常对照组。虽然特应性皮炎患者的可溶性白细胞介素-2受体水平和嗜酸性粒细胞阳离子蛋白水平均与临床严重程度评分显著相关，但嗜酸性粒细胞阳离子蛋白水平与临床严重程度评分之间的相关性高于可溶性白细胞介素-2受体水平与临床严重程度评分之间的相关性。然而，可溶性白细胞介素-2受体水平、嗜酸性粒细胞阳离子蛋白水平和临床严重程度评分与IgE水平均无显著相关性。可溶性白细胞介素-2受体和嗜酸性粒细胞阳离子蛋白水平的时间变化因人而异。然而，在65%的特应性皮炎患者中，可溶性白细胞介素-2受体水平和嗜酸性粒细胞阳离子蛋白水平似乎相互平行。结合临床严重程度评分，检测血清嗜酸性粒细胞阳离子蛋白或可溶性白细胞介素-2受体水平可能是监测特应性皮炎短期或长期疾病活动的有用工具。
