Hilmas D E, Gillette E L
Radiology. 1975 Jul;116(1):165-9. doi: 10.1148/116.1.165.
The microvasculature of C3H/Bi mouse mammary carcinomas 8 mm in average diameter was evaluated using morphometric methods following six consecutive daily exposures of 500 R of x radiation. Tumor volume did not change significantly during the intervals between treatments. Tumors began to grow again 72 hours after the sixth 550-R fraction, with mean vessel length and surface area reaching maximum values and vessel diameters and volumes becoming minimal at this time. These changes were attributed to improved colloidal-carbon filling of previously existing nonfunctional vessles. When anatomically derived estimates of vascular dimensions were related to a metabolically useful blood supply, improved capability for exchange of essential nutrients occurred 72 hours after the sixth 500-R fraction.
对平均直径为8毫米的C3H/Bi小鼠乳腺癌的微血管系统，在连续6天每天接受500伦琴的X射线照射后，采用形态测量法进行评估。在治疗间隔期间，肿瘤体积没有显著变化。在第六次550伦琴剂量照射后72小时，肿瘤开始再次生长，此时平均血管长度和表面积达到最大值，而血管直径和体积则达到最小值。这些变化归因于先前存在的无功能血管的胶体碳填充改善。当从解剖学角度得出的血管尺寸估计值与代谢有用的血液供应相关时，在第六次500伦琴剂量照射后72小时，必需营养物质的交换能力得到改善。
