Horák J, Cuparencu B, Cucuianu M, Opincaru A, Seusan E, Vincze I
Atherosclerosis. 1976 Jul-Aug;24(1-2):81-97. doi: 10.1016/0021-9150(76)90066-6.
Oral administration of the benzodiazepines (diazepam, lorazepam, chlordiazepoxide, bipotassium chlorazepate) in Triton WR-1339-induced (200 mg/kg, blood collection 18 h later) hyperlipidaemia in rats elicited marked decrease of serum total lipids, total cholesterol and triglyceride levels, and alterations in free fatty acid and free glycerol content. The optimal doses for diazepam, lorazepam, chlordiazepoxide and bipotassium chlorazepate were estimated to be 5 mg/kg. Other benzodiazepines, namely oxazepam, medazepam and nitrazepam, elicited only minor changes in serum lipids levels, while with grandaxin no change was observed. The optimal doses of diazepam and lorazepam brought about the same changes in serum lipid content as did clofibrate (90 mg/kg, p. o.). If diazepam, lorazepam, chlordiazepoxide and bipotassium chlorazepate were administered in doses of 5 mg/kg in Triton WR-1339-treated rats (blood collection taken 3 h later), a significant decrease of total lipids and triglyceride levels was observed. The free glycerol level only altered after the administration of chlordiazepoxide, which brought about a significant reduction.
给 Triton WR - 1339 诱导（200 mg/kg，18 小时后采血）的高脂血症大鼠口服苯二氮䓬类药物（地西泮、劳拉西泮、氯氮䓬、氯氮䓬二钾），可使血清总脂质、总胆固醇和甘油三酯水平显著降低，并使游离脂肪酸和游离甘油含量发生改变。地西泮、劳拉西泮、氯氮䓬和氯氮䓬二钾的最佳剂量估计为 5 mg/kg。其他苯二氮䓬类药物，即奥沙西泮、美达西泮和硝西泮，仅引起血清脂质水平的轻微变化，而格鲁米特则未观察到变化。地西泮和劳拉西泮的最佳剂量所引起的血清脂质含量变化与氯贝丁酯（90 mg/kg，口服）相同。如果在 Triton WR - 1339 处理的大鼠中（3 小时后采血）以 5 mg/kg 的剂量给予地西泮、劳拉西泮、氯氮䓬和氯氮䓬二钾，可观察到总脂质和甘油三酯水平显著降低。仅在给予氯氮䓬后游离甘油水平发生改变，导致其显著降低。
