Sinha M, Ghosh A K
Department of Biochemistry, University College of Medicine, Calcutta.
Indian J Med Res. 1994 Mar;99:133-6.
Oral administration of large doses of retinol to young rats significantly accelerated glucose and galactose uptake in small intestinal segments. It also augmented both total and specific activities of brush border membrane associated disaccharidases and blood glucose level. For this investigation the intestine was examined in three segments viz., proximal, mid and distal portion and also as a whole. In comparison with matched controls, total enzymic activities in with hypervitaminosis A animals were nearly double for lactase, sucrase and maltase in all segments. With specific enzymic activities, the change in enzymic activities were greater for lactase and maltase, but less for sucrase.
给幼鼠口服大剂量视黄醇可显著加速小肠段对葡萄糖和半乳糖的摄取。它还提高了刷状缘膜相关双糖酶的总活性和比活性以及血糖水平。在本研究中，对小肠的三个部分，即近端、中段和远端部分以及整个小肠进行了检查。与匹配的对照组相比，维生素A过多症动物所有肠段中乳糖酶、蔗糖酶和麦芽糖酶的总酶活性几乎是对照组的两倍。就比酶活性而言，乳糖酶和麦芽糖酶的酶活性变化更大，而蔗糖酶的变化较小。
