Obasi S C, Njoku O U, Obidoa O
School of Biological Sciences, Abia State University, Uturu, Nigeria.
Indian J Physiol Pharmacol. 1994 Apr;38(2):89-94.
The plasma cholesterol and phospholipid levels as well as the bleeding time of chicks treated with single oral doses of scopoletin (60 micrograms/kg, body wt) and aflatoxin B1 (50 micrograms/kg, body wt) were measured at intervals for a period of one week (168 h). Both compounds generally increased the bleeding time (AFB1 0.8-28.7%, Scopoletin 0.5-38.2%), serum total and free cholesterol, and the serum phospholipid levels but decreased the levels of the serum esterified cholesterol fraction relative to control throughout the period of study. The extent of these changes elicited by the respective compounds and the variation in the differences between their respective effects varied with the measured parameters. The importance of the similarities in the effects elicited by aflatoxin B1 and Scopoletin was highlighted.
对单次口服东莨菪素（60微克/千克体重）和黄曲霉毒素B1（50微克/千克体重）处理的雏鸡，在一周（168小时）内定期测量其血浆胆固醇和磷脂水平以及出血时间。在整个研究期间，这两种化合物通常都会延长出血时间（黄曲霉毒素B1延长0.8 - 28.7%，东莨菪素延长0.5 - 38.2%），增加血清总胆固醇和游离胆固醇以及血清磷脂水平，但相对于对照组，血清酯化胆固醇部分的水平会降低。各化合物引起的这些变化程度以及它们各自效应之间差异的变化随所测参数而不同。强调了黄曲霉毒素B1和东莨菪素所引发效应相似性的重要性。
