黄荆叶的一般药理学

General pharmacology of Vitex leucoxylon Linn leaves.

作者信息

Makwana H G, Ravishankar B, Shukla V J, Nair R B, Vijayan N P, Sasikala C K, Saraswathy V N, Bhatt S V

机构信息

Institute for P. G. Teaching and Research, Jamnagar.

出版信息

Indian J Physiol Pharmacol. 1994 Apr;38(2):95-100.

PMID:8063369

Abstract

Ethanol extract (ETE) and cold aqueous infusion (CAI) of Vitex leucoxylon leaf were evaluated in a battery of tests to define the activity profile of the plant. CAI depressed SMA, antagonised d-amphetamine stereotypy and oxotremorine tremors, shortened the duration of mice immobility in behavioural 'despair' test and lowered serum total cholesterol level. ETE showed significant inhibition of carrageenin paw oedema and granulation tissue formation in rats. Suppression of acetic acid writhing was observed with both ETE and CAI. LD50 value of ETE was > 3000 mg kg-1 (ip) and that of CAI 1050 (800-1200) mgkg-1.

摘要

对黄荆叶的乙醇提取物（ETE）和冷浸液（CAI）进行了一系列测试，以确定该植物的活性特征。CAI可降低自发运动活动，拮抗右旋苯丙胺刻板行为和氧化震颤素震颤，缩短小鼠在行为“绝望”试验中的不动时间，并降低血清总胆固醇水平。ETE对大鼠角叉菜胶性足肿胀和肉芽组织形成有显著抑制作用。ETE和CAI均能抑制醋酸扭体反应。ETE的半数致死量值>3000 mg kg-1（腹腔注射），CAI的半数致死量值为1050（800 - 1200）mg kg-1。