Generalized vitiligo preceded by a generalized figurate erythematosquamous eruption.

The pathogenesis of vitiligo is still unknown. We saw a patient with vitiligo who may support an immunological pathogenesis for this disease. A 77-year-old man developed sharply demarcated, irregularly shaped, figurate, erythematosquamous plaques on most of the areas of his body. Histologically, lymphocytic cells invaded the lower epidermis. The lesions were gradually replaced by vitiliginous macules of the same configuration. Histologically, there were no active melanocytes in the vitiliginous lesions. We believe that the present patient presents an extraordinary example of inflammatory vitiligo and may provide an indication of an immunological pathogenesis for vitiligo.