Arata J, Abe-Matsuura Y
Department of Dermatology, Okayama University Medical School, Japan.
J Dermatol. 1994 Jun;21(6):438-41. doi: 10.1111/j.1346-8138.1994.tb01770.x.
The pathogenesis of vitiligo is still unknown. We saw a patient with vitiligo who may support an immunological pathogenesis for this disease. A 77-year-old man developed sharply demarcated, irregularly shaped, figurate, erythematosquamous plaques on most of the areas of his body. Histologically, lymphocytic cells invaded the lower epidermis. The lesions were gradually replaced by vitiliginous macules of the same configuration. Histologically, there were no active melanocytes in the vitiliginous lesions. We believe that the present patient presents an extraordinary example of inflammatory vitiligo and may provide an indication of an immunological pathogenesis for vitiligo.
白癜风的发病机制仍然不明。我们见到了一名白癜风患者，其情况可能支持该病的免疫发病机制。一名77岁男性在其身体大部分部位出现了边界清晰、形状不规则、图形状的红斑鳞屑性斑块。组织学检查显示，淋巴细胞侵入了表皮下层。这些皮损逐渐被相同形态的白癜风斑所取代。组织学检查发现，白癜风皮损中没有活跃的黑素细胞。我们认为，该患者是炎症性白癜风的一个特殊病例，可能为白癜风的免疫发病机制提供了线索。
