Tamer Funda
Medical Park Hastanesi, Yenimahalle, Ankara, Turkey.
Acta Dermatovenerol Alp Pannonica Adriat. 2016 Dec;25(4):77-78. doi: 10.15570/actaapa.2016.22.
Erythema dyschromicum perstans is a rare, chronic, pigmentary disorder with unknown etiology. It clinically presents with oval to round, gray, blue, or brown macules of various sizes. The etiology remains unknown; however, cobalt allergy, radio contrast media, intestinal parasites, human immunodeficiency virus, and hypothyroidism have been proposed as causative factors. In addition, vitiligo is characterized by depigmented macules and patches that are widely andsymmetrically distributed. It has been suggested that autoimmune mechanisms play an important role in the etiopathogenesis of vitiligo. Physical and emotional stress can trigger vitiligo in genetically predisposed patients. However, coexistence of erythema dyschromicum perstans and vitiligo is extremely rare, and similar immune mechanisms have been implicated in the pathogenesis of these cutaneous pigmentary disorders.
持久性色素异常性红斑是一种罕见的慢性色素沉着性疾病，病因不明。临床上表现为大小不一的椭圆形至圆形灰色、蓝色或棕色斑疹。病因仍不清楚；然而，有人提出钴过敏、放射造影剂、肠道寄生虫、人类免疫缺陷病毒和甲状腺功能减退是致病因素。此外，白癜风的特征是色素脱失斑和斑块广泛对称分布。有人认为自身免疫机制在白癜风的发病机制中起重要作用。身体和情绪压力可在有遗传易感性的患者中诱发白癜风。然而，持久性色素异常性红斑和白癜风同时存在极为罕见，且这些皮肤色素沉着性疾病的发病机制涉及相似的免疫机制。
