Chaloupka V, Mitchell S, Muirhead R
Physics Department and School of Music, University of Washington, Seattle 98195.
J Acoust Soc Am. 1994 Jul;96(1):145-9. doi: 10.1121/1.411437.
This paper reports a study of an absolute pitch possessor who, upon administration of the psychoactive drug Tegratol (carbamazepine), experienced a significant change in her pitch perception. The subject's performance both in producing, as well as in identifying, random-frequency tones was measured, covering the period of administration of the drug, as well as control periods before and after. The main effect of the drug was a downward shift of the perceived pitch as compared to the two control periods. The magnitude of the shift was observed to increase with increasing fundamental frequency of the stimulus; the average shift was about one semitone. Detailed results on the frequency dependence and time dependence of the pitch shifts are presented. This may be the first documented report of a significant, reversible change of pitch perception caused by a medication.
本文报道了一项关于绝对音高拥有者的研究，该拥有者在服用精神活性药物 Tegratol（卡马西平）后，其音高感知发生了显著变化。测量了该受试者在药物服用期间以及服药前后的对照期内生成和识别随机频率音调的表现。与两个对照期相比，药物的主要作用是感知音高向下偏移。观察到偏移幅度随刺激基频的增加而增大；平均偏移约为一个半音。文中给出了音高偏移的频率依赖性和时间依赖性的详细结果。这可能是关于药物引起音高感知显著且可逆变化的首篇有记录报告。
