Williams J G, Heine J A, Stoller D L, Rothenberger D A
Division of Colon and Rectal Surgery, University of Minnesota, Minneapolis 55455.
Int J Colorectal Dis. 1994 May;9(2):100-4. doi: 10.1007/BF00699422.
Functional outcome following restorative proctocolectomy depends, in part, on the volume of the pouch. This study investigates the relationship between the length of ileum and volume of saline required to distend the ileum to a set pressure, and the possibility of predicting the volume of an ileoanal pouch using these measurements. Measurements were made on the ileum of 8 mongrel dogs. There was a linear relationship between the length of ileum and volume of saline infused to produce an intraluminal pressure of 20 mmHg (r = 0.94-0.99). However, the capacity of ileum varied widely from animal to animal (100 cc of saline filled 15.5 cm to 43 cm of ileum). Twenty-four pouches (15J, 9S) were constructed from segments of ileum of known capacity. The capacity of a J pouch was 1.71 +/- 0.11 times greater than the capacity of the original length of bowel and an S pouch had a capacity 2.14 +/- 0.25 times greater. These changes in capacity are similar to a theoretical calculation of change in volume of ileum after pouch construction. This technique is a simple, quick method of predicting the volume of an ileo-anal pouch which will be useful in a clinical trial to compare function of pouches of different volumes.
保留性直肠结肠切除术后的功能结果部分取决于贮袋的容积。本研究调查了回肠长度与将回肠扩张至设定压力所需生理盐水容积之间的关系，以及使用这些测量值预测回肠肛管贮袋容积的可能性。对8只杂种狗的回肠进行了测量。回肠长度与注入生理盐水以产生20 mmHg腔内压力的容积之间存在线性关系（r = 0.94 - 0.99）。然而，不同动物的回肠容量差异很大（100 cc生理盐水可充盈15.5 cm至43 cm的回肠）。用已知容量的回肠段构建了24个贮袋（15个J型，9个S型）。J型贮袋的容量比原肠段长度的容量大1.71 +/- 0.11倍，S型贮袋的容量大2.14 +/- 0.25倍。这些容量变化与贮袋构建后回肠容积变化的理论计算结果相似。该技术是一种简单、快速的预测回肠肛管贮袋容积的方法，在比较不同容积贮袋功能的临床试验中将很有用。
