Kulkarni A D, Rudolph F B, Van Buren C T
Department of Surgery, University of Texas Medical School at Houston 77030.
J Nutr. 1994 Aug;124(8 Suppl):1442S-1446S. doi: 10.1093/jn/124.suppl_8.1442S.
Dietary sources of preformed purines and pyrimidines seem to be important for optimal function of the cellular immune response. It was previously assumed that nucleotides were not needed for normal growth and development, but the results described in this review demonstrate a need for nucleotides in the response to immunological challenges. This effect is likely due to a requirement for preformed pyrimidines for proper development and activation of T cells. The need for sources of preformed nucleotides in defined formulas such as parenteral and enteral formulas and infant formulas is suggested by the studies reviewed below.
预制嘌呤和嘧啶的膳食来源似乎对细胞免疫反应的最佳功能很重要。以前人们认为正常生长发育不需要核苷酸，但本综述中描述的结果表明，在应对免疫挑战时需要核苷酸。这种作用可能是由于需要预制嘧啶来促进T细胞的正常发育和激活。以下综述的研究表明，在诸如肠外和肠内配方以及婴儿配方等特定配方中需要预制核苷酸来源。
