Chandra R K, Kumari S
Department of Pediatrics, Memorial University of Newfoundland, Canada.
J Nutr. 1994 Aug;124(8 Suppl):1433S-1435S. doi: 10.1093/jn/124.suppl_8.1433S.
Historical accounts and recent epidemiologic studies have suggested a mutually aggravating relationship between malnutrition and infection. In protein-energy malnutrition, there is a significant impairment of several aspects of immunity, including cell-mediated immune responses, secretory immunoglobulin A antibody production, phagocyte function, complement system, antibody affinity and cytokine production. Several micronutrients play a crucial role in maintenance of optimum immune responses. On the other hand, excessive intake of nutrients also impairs immunity. Animals fed diets lacking in nucleotides have lower immune responses than controls but there is no enhancement of immunity when the diet contains large amounts of nucleotides. These observations have considerable practical importance in terms of designing feeding formulas.
历史记载和近期的流行病学研究表明，营养不良与感染之间存在相互加剧的关系。在蛋白质 - 能量营养不良中，免疫的多个方面存在显著损害，包括细胞介导的免疫反应、分泌型免疫球蛋白A抗体产生、吞噬细胞功能、补体系统、抗体亲和力和细胞因子产生。几种微量营养素在维持最佳免疫反应中起着关键作用。另一方面，营养物质摄入过多也会损害免疫力。喂食缺乏核苷酸饮食的动物的免疫反应低于对照组，但当饮食中含有大量核苷酸时，免疫力并没有增强。这些观察结果在设计喂养配方方面具有相当大的实际重要性。
