Colu R, Clermont M J, Letarte J, Leboeuf G, Ducharme J R
Endocr Res Commun. 1975;2(2):123-35. doi: 10.1080/07435807509053843.
TRH antagonized the GH releasing effect of pentobarbital anesthesia as well in normal as in thyroidectomized rats, and significantly increased plasma B levels in normal animals. This effect was also observed when TRH was administered into a lateral ventricle of the brain in ug amounts, and was suppressed by the beta-adrenergic receptor blocker propranolol. T3 also antagonized the pentobarbital-induced release of GH; however, plasma B levels were not modified, and the effect on plasma GH levels was not suppressed by propranolol.
促甲状腺激素释放激素（TRH）在正常大鼠和甲状腺切除的大鼠中，均能拮抗戊巴比妥麻醉的生长激素释放效应，并且能显著提高正常动物的血浆B水平。当以微克量将TRH注入脑侧脑室时，也观察到了这种效应，且该效应被β-肾上腺素能受体阻滞剂普萘洛尔所抑制。三碘甲状腺原氨酸（T3）也能拮抗戊巴比妥诱导的生长激素释放；然而，血浆B水平未发生改变，且对血浆生长激素水平的效应未被普萘洛尔抑制。
