Collu R, Clermont M J, Ducharme J R
Eur J Pharmacol. 1976 May;37(1):133-40. doi: 10.1016/0014-2999(76)90016-9.
Thyrotropin-releasing hormone (TRH) injected either IP (10 mg/kg) or intraventricularly (10 mug/rat) antagonized the pentobarbital-induced secretion of prolactin (PRL). This effect was not blocked by propranolol. In thyroidectomized animals the effect was not apparent; tri-iodothyronine (T3) injection was however ineffective. The injections of luteinizing hormone-releasing hormone (LH-RH) and of melanocyte stimulating hormone release-inhibiting factor (MIF) were also ineffective. Of six TRH analogues, only those containing histidine antagonized pentobarbital-induced PRL release, but none modified plasma levels of growth hormone (GH) or corticosterone (B). Brain levels of serotonin (5-HT) and 5-hydroxyindoleacetic acid (5-HIAA) were not modified by TRH. Morphine-induced secretion of PRL and GH was also significantly antagonized by TRH. Since pentobarbital and morphine-induced hormonal changes are probably exerted through a central nervous system depressant action, these data indicate that TRH can influence brain activity through an extrapituitary mechanism.
经腹腔注射（10毫克/千克）或脑室内注射（10微克/大鼠）的促甲状腺激素释放激素（TRH）可拮抗戊巴比妥诱导的催乳素（PRL）分泌。这种作用不会被普萘洛尔阻断。在甲状腺切除的动物中，这种作用并不明显；然而，注射三碘甲状腺原氨酸（T3）无效。注射促黄体生成素释放激素（LH-RH）和促黑素细胞激素释放抑制因子（MIF）也无效。在六种TRH类似物中，只有含有组氨酸的类似物能拮抗戊巴比妥诱导的PRL释放，但无一能改变生长激素（GH）或皮质酮（B）的血浆水平。TRH不会改变脑中血清素（5-HT）和5-羟吲哚乙酸（5-HIAA）的水平。TRH也能显著拮抗吗啡诱导的PRL和GH分泌。由于戊巴比妥和吗啡诱导的激素变化可能是通过中枢神经系统抑制作用产生的，这些数据表明TRH可通过垂体外机制影响脑活动。
