Korenek N L, Legendre A M, Andrews F M, Blackford J T, Wan P Y, Breider M A, Rinaldi M G
Department of Rural Practice, College of Veterinary Medicine, University of Tennessee, Knoxville.
J Vet Intern Med. 1994 May-Jun;8(3):224-7. doi: 10.1111/j.1939-1676.1994.tb03221.x.
Itraconazole, a third-generation azole, was evaluated for treatment of resistant nasal mycotic infections in horses. Two horses with Aspergillus spp nasal granulomas and 1 horse with Conidiobolus coronatus nasal infection were treated with itraconazole (3 mg/kg PO bid). One of the horses with nasal aspergillosis was also treated by surgical resection of the nasal septum. The treatment time for the horses ranged from 3 to 4.5 months. No adverse effects were noted in any of the horses during the treatment period. Peak and trough serum itraconazole concentrations were < 0.5 micrograms/mL in all 3 horses. Itraconazole (3 mg/kg PO bid) appears to be effective in the treatment of nasal Aspergillus spp infections in horses because the fungal infection was eliminated in both horses. One horse still had excessive nasal sounds during exercise and was retired from training, whereas the other horse returned to normal. The nasal C. coronatus infection appeared resistant to itraconazole treatment in the affected horse because the granulomas were still present after 4.5 months of treatment.
伊曲康唑是一种第三代唑类药物，对其治疗马顽固性鼻霉菌感染进行了评估。对两匹患有曲霉菌属鼻肉芽肿的马和一匹患有冠状耳霉鼻感染的马使用伊曲康唑（口服，3mg/kg，每日两次）进行治疗。其中一匹患有鼻曲霉菌病的马还接受了鼻中隔手术切除治疗。这些马的治疗时间为3至4.5个月。在治疗期间，所有马匹均未出现不良反应。所有3匹马的血清伊曲康唑峰浓度和谷浓度均<0.5微克/毫升。伊曲康唑（口服，3mg/kg，每日两次）似乎对治疗马鼻曲霉菌属感染有效，因为两匹马的真菌感染均已消除。一匹马在运动时仍有过多鼻音，退出训练，而另一匹马恢复正常。受感染马的鼻冠状耳霉感染似乎对伊曲康唑治疗有抗性，因为治疗4.5个月后肉芽肿仍然存在。
