Walz LeBlanc B A, Dagenais P, Urowitz M B, Gladman D D
Lupus Clinic, Wellesley Hospital, Toronto, ON, Canada.
J Rheumatol. 1994 May;21(5):836-8.
Methotrexate (MTX) has been used successfully in the treatment of rheumatoid arthritis, psoriatic arthritis, polymyositis, and Reiter's syndrome. Our objective was to determine the effectiveness of MTX in the treatment of systemic lupus erythematosus (SLE).
We reviewed retrospectively MTX therapy in 5 patients with SLE, 3 with renal disease and 2 with arthritis.
MTX therapy was well tolerated and effective in all 5 patients.
MTX appears to be both effective and well tolerated in patients with SLE.
甲氨蝶呤（MTX）已成功用于治疗类风湿关节炎、银屑病关节炎、多发性肌炎和赖特综合征。我们的目的是确定MTX治疗系统性红斑狼疮（SLE）的有效性。
我们回顾性分析了5例SLE患者的MTX治疗情况，其中3例有肾脏疾病，2例有关节炎。
所有5例患者对MTX治疗耐受性良好且有效。
MTX在SLE患者中似乎既有效且耐受性良好。
