Rosenstein E D, Kunicka J, Kramer N, Goldstein G
Immunobiology Research Institute, Annandale, NJ 08801-0999.
J Rheumatol. 1994 May;21(5):901-4.
Nonsteroidal antiinflammatory drugs have been thought to act by inhibiting the enzyme, cyclooxygenase (prostaglandin H synthetase). We sought to demonstrate additional biologic actions of this class of drugs including effects on cytokine production.
We administered the nonsteroidal antiinflammatory drug piroxicam 20 mg to 6 healthy volunteers daily for 7 days. Before and for one week after drug administration, concentrations of interleukin 1 (IL-1), IL-2, IL-4, IL-6, tumor necrosis factor alpha (TNF alpha) and interferon-gamma (IFN-gamma), produced by anti-CD3 stimulated peripheral blood mononuclear cells, were measured.
Piroxicam treatment resulted in elevation of levels of IL-2, depression of IL-1, IL-6, TNF alpha and IFN-gamma, and no consistent effect on IL-4.
Piroxicam modulates production of various cytokines in a complex fashion when administered to healthy individuals.
非甾体抗炎药被认为是通过抑制环氧化酶（前列腺素H合成酶）发挥作用。我们试图证明这类药物的其他生物学作用，包括对细胞因子产生的影响。
我们给6名健康志愿者每日服用20毫克非甾体抗炎药吡罗昔康，持续7天。在给药前及给药后一周，检测抗CD3刺激的外周血单核细胞产生的白细胞介素1（IL-1）、IL-2、IL-4、IL-6、肿瘤坏死因子α（TNFα）和干扰素-γ（IFN-γ）的浓度。
吡罗昔康治疗导致IL-2水平升高，IL-1、IL-6、TNFα和IFN-γ水平降低，对IL-4无一致影响。
给健康个体服用吡罗昔康时，它以复杂的方式调节多种细胞因子的产生。
