Hirabayashi N, Goto S, Isogai C, Tomita A, Ohno T
Department of Hematology, Nagoya Daini Red Cross Hospital.
Rinsho Ketsueki. 1994 Jul;35(7):710-2.
A case of successful pregnancy after allogeneic bone marrow transplantation (BMT) in a woman with severe aplastic anemia conditioned with 200 mg/kg cyclophosphamide and 4.5 Gy total lymphoid irradiation (TLI) at the age of 15 years is reported. She delivered a normal child 92 months after BMT. A male with paroxysmal nocturnal hemoglobinuria received allogeneic BMT at the age of 22 years is described as a second case. He was conditioned with 200 mg/kg CY and 7.5 Gy TLI and parented a normal child 32 months after BMT. These observations demonstrate that normal pregnancy can follow high dose chemotherapy and TLI.
报告了一例15岁严重再生障碍性贫血女性患者，接受200mg/kg环磷酰胺和4.5Gy全身淋巴结照射（TLI）预处理后进行异基因骨髓移植（BMT）并成功妊娠的病例。她在BMT后92个月分娩了一个正常婴儿。第二例是一名22岁患阵发性夜间血红蛋白尿的男性接受了异基因BMT。他接受了200mg/kg环磷酰胺和7.5Gy TLI预处理，并在BMT后32个月育有一个正常孩子。这些观察结果表明，高剂量化疗和TLI后可以实现正常妊娠。
