Marumo K, Nakamura Y
Department of Clinical Pathology, Showa University Fujigaoka Hospital, Yokohama.
Rinsho Byori. 1994 Jul;42(7):731-6.
Effect of chlorhexidine gluconate (CHG) on 98 clinical isolates of Serratia marcescens, previously O-serotyped, in The Showa University Fujigaoka Hospital (1989. 1-1991. 3) was investigated. The serotype O3 group (28 strains) was more frequently isolated than any other groups and more resistant to 28 different antimicrobial agents tested. 18 (50%) of 36 strains (MIC of CHG > or = 100 micrograms/ml) were serotype O3 and MIC-distribution of CHG for total O3 strains was more resistant than that for the other serotype strains. Bactericidal effect of CHG on 18 O3 strains (MIC of CHG > or = 100 micrograms/ml) was significantly lower than on the other 10 strains (MIC of CHG < or = 50 micrograms/ml). Although 19 (68%) of total O3 strains were resistant to cefotaxime and the other drugs, MIC-distribution of CHG for these strains was not associated with the antimicrobial resistance tested. The above results, at least, suggest that the serotype O3 group is suited for residing in hospitalized patients more than any other serotype groups.
研究了昭和大学藤冈医院（1989年1月 - 1991年3月）中葡萄糖酸氯己定（CHG）对98株先前已进行O血清分型的粘质沙雷氏菌临床分离株的影响。O3血清型组（28株）比其他任何组更频繁地被分离出来，并且对测试的28种不同抗菌药物更具抗性。36株菌株（CHG的最低抑菌浓度≥100微克/毫升）中有18株（50%）为O3血清型，CHG对所有O3菌株的最低抑菌浓度分布比其他血清型菌株更具抗性。CHG对18株O3菌株（CHG的最低抑菌浓度≥100微克/毫升）的杀菌效果明显低于对其他10株菌株（CHG的最低抑菌浓度≤50微克/毫升）的杀菌效果。虽然所有O3菌株中有19株（68%）对头孢噻肟和其他药物耐药，但CHG对这些菌株的最低抑菌浓度分布与所测试的抗菌药物耐药性无关。上述结果至少表明，O3血清型组比其他任何血清型组更适合在住院患者中定植。
